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Facts About Dry Eye and Meibomian Gland Expressions

The information contained below will allow the reader to achieve a better understanding of dry eyes and treatments including meibomian gland expressions.

For more information, consult our website for Dry Eyes Los Angeles at www.dryeyeslosangeles.com.

This information was developed by the National Eye Institute to help patients and their families search for general information about dry eye.  An eye care professional who has examined the patient’s eyes and is familiar with his or her medical history is the best person to answer specific questions.

What is dry eye?

Dry eye occurs when the eye does not produce tears properly, or when the tears are not of the correct consistency and evaporate too quickly. In addition, inflammation of the surface of the eye may occur along with dry eye. If left untreated, this condition can lead to pain, ulcers, or scars on the cornea, and some loss of vision. However, permanent loss of vision from dry eye is uncommon.

Dry eye can make it more difficult to perform some activities, such as using a computer or reading for an extended period of time, and it can decrease tolerance for dry environments, such as the air inside an airplane. Other names for dry eye include dry eye syndrome, keratoconjunctivitis sicca (KCS), dysfunctional tear syndrome, lacrimal keratoconjunctivitis, evaporative tear deficiency, aqueous tear deficiency, and LASIK-induced neurotrophic epitheliopathy (LNE).

What are the types of dry eye?

1) Aqueous tear-deficient dry eye is a disorder in which the lacrimal glands fail to produce enough of the watery component of tears to maintain a healthy eye surface.

2) Evaporative dry eye may result from inflammation of the meibomian glands, also located in the eyelids. These glands make the lipid or oily part of tears that slows evaporation and keeps the tears stable.

Dry eye can be associated with inflammation of the surface of the eye, the lacrimal gland, or the conjunctiva. In addition, it can be associated with any disease process that alters the composition of the tears or the surface of the eyes such as thyroid disease. 

What is the cornea?

The cornea is the clear, dome-shaped outer surface that covers the eye in front of the iris, the colored part of the eye. The cornea helps protect the rest of the eye from germs, dust, and other harmful matter. The cornea bends, or refracts, light entering the eye, and accounts for most of the eye’s total focusing power. It also serves as a filter to screen out most of the damaging ultraviolet (UV) wavelengths in sunlight.

The cornea is a highly organized, clear structure made up of a group of cells and proteins precisely arranged in layers, but it has no blood vessels to nourish or protect it against infection. Instead, it receives its nourishment from the tears and the watery fluid (aqueous humor) that fills the chamber behind it.

What are tears, and how do they relate to dry eye?

Tears, made by the lacrimal gland, are necessary for overall eye health and clear vision. Tears bathe the surface of the eye, keeping it moist, and wash away dust and debris. They also help protect the eye from bacterial and other types of infections. Tears are composed of three major components: a) outer, oily, lipid layer produced by the meibomian glands; b) middle, watery, lacrimal layer produced by the lacrimal glands; and c) inner, mucous or mucin layer produced by goblet cells located within a thin transparent layer over the white part of the eye and covering the inner surface of the eyelids. Tears are made of proteins (including growth factors), electrolytes, and vitamins that are critical to maintain the health of the eye surface and to prevent infection.

Tears are constantly produced to bathe, nourish, and protect the eye surface. They are also produced in response to emergencies, such as a particle of dust in the eye, an infection or irritation of the eye, or an onset of strong emotions. When the lacrimal glands fail to produce sufficient tears, dry eye can result. Any disease process that alters the components of tears can make them unhealthy and result in dry eye.

What are the symptoms of dry eye?

Dry eye symptoms may include any of the following:

stinging or burning of the eye;
a sandy or gritty feeling as if something is in the eye;
episodes of excess tears following very dry eye periods;
a stringy discharge from the eye;
pain and redness of the eye;
episodes of blurred vision;
heavy eyelids;
inability to cry when emotionally stressed;
uncomfortable contact lenses;
decreased tolerance of reading, working on the computer, or any activity that requires sustained visual attention;
eye fatigue.
NOTE: If symptoms of dry eye persist, consult an eye care professional to get an accurate diagnosis of the condition and begin treatment to avoid permanent damage.

What are the causes of dry eye?

Dry eye can be a temporary or chronic condition:

Dry eye can be a side effect of some medications, including antihistamines, nasal decongestants, tranquilizers, certain blood pressure medicines, Parkinson’s medications, birth control pills and anti-depressants.
Skin disease on or around the eyelids can result in dry eye.
Diseases of the glands in the eyelids, such as meibomian gland dysfunction, can cause dry eye.
Dry eye can occur in women who are pregnant.
Women who are on hormone replacement therapy may experience dry eye symptoms. Women taking only estrogen are 70 percent more likely to experience dry eye, whereas those taking estrogen and progesterone have a 30 percent increased risk of developing dry eye.
Dry eye can also develop after the refractive surgery known as LASIK. These symptoms generally last three to six months, but may last longer in some cases.
Dry eye can result from chemical and thermal burns that scar the membrane lining the eyelids and covering the eye.
Allergies can be associated with dry eye.
Infrequent blinking, associated with staring at computer or video screens, may also lead to dry eye symptoms.
Both excessive and insufficient dosages of vitamins can contribute to dry eye.
Homeopathic remedies may have an adverse impact on a dry eye condition.
Loss of sensation in the cornea from long-term contact lens wear can lead to dry eye.
Dry eye can be associated with immune system disorders such as Sjögren’s syndrome, lupus, and rheumatoid arthritis. Sjögren’s leads to inflammation and dryness of the mouth, eyes, and other mucous membranes. It can also affect other organs, including the kidneys, lungs and blood vessels.
Dry eye can be a symptom of chronic inflammation of the conjunctiva, the membrane lining the eyelid and covering the front part of the eye, or the lacrimal gland. Chronic conjunctivitis can be caused by certain eye diseases, infection, exposure to irritants such as chemical fumes and tobacco smoke, or drafts from air conditioning or heating.
If the surface area of the eye is increased, as in thyroid disease when the eye protrudes forward or after cosmetic surgery if the eyelids are opened too widely, dry eye can result.
Dry eye may occur from exposure keratitis, in which the eyelids do not close completely during sleep.

Who is likely to develop dry eye?

Elderly people frequently experience dryness of the eyes, but dry eye can occur at any age. Nearly five million Americans 50 years of age and older are estimated to have dry eye. Of these, more than three million are women and more than one and a half million are men. Tens of millions more have less severe symptoms. Dry eye is more common after menopause. Women who experience menopause prematurely are more likely to have eye surface damage from dry eye.

How is dry eye treated?

Depending on the causes of dry eye, your doctor may use various approaches to relieve the symptoms. Dry eye can be managed as an ongoing condition. The first priority is to determine if a disease is the underlying cause of the dry eye (such as Sjögren’s syndrome or lacrimal and meibomian gland dysfunction). If it is, then the underlying disease needs to be treated.

Cyclosporine, an anti-inflammatory medication, is the only prescription drug available to treat dry eye. It decreases corneal damage, increases basic tear production, and reduces symptoms of dry eye. It may take three to six months of twice-a-day dosages for the medication to work. In some cases of severe dry eye, short term use of corticosteroid eye drops that decrease inflammation is required.

If dry eye results from taking a medication, your doctor may recommend switching to a medication that does not cause the dry eye side effect.

If contact lens wear is the problem, your eye care practitioner may recommend another type of lens or reducing the number of hours you wear your lenses. In the case of severe dry eye, your eye care professional may advise you not to wear contact lenses at all.

Another option is to plug the drainage holes, small circular openings at the inner corners of the eyelids where tears drain from the eye into the nose. Lacrimal plugs, also called punctal plugs, can be inserted painlessly by an eye care professional. The patient usually does not feel them. These plugs are made of silicone or collagen, are reversible, and are a temporary measure. In severe cases, permanent plugs may be considered.

In some cases, a simple surgery, called punctal cautery, is recommended to permanently close the drainage holes. The procedure helps keep the limited volume of tears on the eye for a longer period of time.

In some patients with dry eye, supplements or dietary sources (such as tuna fish) of omega-3 fatty acids (especially DHA and EPA) may decrease symptoms of irritation. The use and dosage of nutritional supplements and vitamins should be discussed with your primary medical doctor.

Treatment Options: Consider Meibomian Gland Expression

We can treat the oil glands at the margins of your eyelids (meibomian glands) to influence them to create more oil. Many times this oil becomes blocked as it thickens with age and infrequent blinking. By removing the thickened saturated oil from the blocked portions of the meibomian glands we can get the good oil to begin to flow again. This will allow patients to keep more of their own tears before they evaporate. Many conditions contribute to this blockage of the meibomian glands. A primary culprit is called blepharitis. All these issues can be treated at our Dry Eye Clinic. In addition, Omega Three supplements are often recommended as well as special blinking exercises that allow the oil glands to regain function. We do meibomian gland expression in our office and the procedure is done by our doctors rather than by using a machine. This allows us to perform the procedure at a significantly reduced cost.

What can I do to help myself?
Use artificial tears, gels, gel inserts, and ointments – available over the counter – as the first line of therapy. They offer temporary relief and provide an important replacement of naturally produced tears in patients with aqueous tear deficiency. Avoid artificial tears with preservatives if you need to apply them more than four times a day or preparations with chemicals that cause blood vessels to constrict.
Wearing glasses or sunglasses that fit close to the face (wrap around shades) or that have side shields can help slow tear evaporation from the eye surfaces. Indoors, an air cleaner to filter dust and other particles helps prevent dry eyes. A humidifier also may help by adding moisture to the air.
Avoid dry conditions and allow your eyes to rest when performing activities that require you to use your eyes for long periods of time. Instill lubricating eye drops while performing these tasks.
Blink your eyes as much as you can when using a computer or looking at your cell phone or tablet device.
The blinking mechanism stimulates the flow of oil from oil glands at the base of your eyelashes and helps keep your own tears from evaporating.
Blink Exercises
Because we do not blink enough when we are looking at our phones, computers, lap tops and flat screen TV’s we are not causing a release of the oil that is in our oil glands. These oil glands, called Meibomian glands, express this oil when we make a proper blink and this oil works its way into our tears. Proper blinking involves a full blink. There is an exercise that patients can do to help them learn how to blink properly. Here is how it goes: First we have to learn how to blink properly. To enable this, hold your index fingers at the outsides part of your eyes. Close your eyes and try to close them without feeling that the skin under your fingers moves. It sort of feels like you are trying to move just the upper eyelids and not the lower part of the eyes. This is how the normal blink is supposed to feel. To really get the oil glands to squeeze out the oil you need to periodically squeeze the lids closed. In this blink, it is OK to feel that the tissue moves under your fingers. Practice this sequence: Close-Pause-Pause- Open-Relax (the close in this sequence is with feeling that just the upper lids are closing and you do not feel the skin moving under your fingers). Close-Pause-Pause-Squeeze-Open-Relax (Here you are feeling the squeezing of the lids as they are being closed and this is the sequence where the oil is released).